According to statistics, about 45% of active pharmaceutical ingredients face the challenge of preparing medicines due to low dissolution rate and solubility in water.
These difficulties not only affect the bioavailability of drugs, but also limit the full play of their effects. The emergence of wet nano grinding technology provides new hope for these insoluble drugs.
When the particle size is reduced to 100-200nm, the dissolution rate and solubility of the drug increase.
01
The principle and advantage of drug nanocrystalline
Drug nanocrystals refer to the refinement of drug particles to the nanometer level, thereby increasing their specific surface area, thereby enhancing the dissolution rate and solubility.
This technology is based on nanoscale effects, by reducing the particle size, making it easier for drug molecules to come into contact with water molecules, thus speeding up the dissolution rate and improving bioavailability.
Drug nano has become an important direction to improve drug performance and promote new drug research and development.
02
The working principle of wet nano lapping technology
Wet nano grinding technology is a top-down preparation process, in the sand mill, it is necessary to pre-fill a certain proportion of grinding media, these media under high-speed rotation to produce huge energy, effectively break the bulk drug particles.
Through the collision and extrusion between the grinding medium and the rotor in the liquid, the drug particles are gradually refined to the nanometer level.
Picture: Boyi 0.3L nano pharmaceutical experimental machine, self-circulating grinding system, supporting CIP/SIP
The size of the grinding medium, the material and the grinding parameters (such as speed, time, temperature) have an important effect on the particle size distribution of the final material.
03
Effect of grinding parameters on particle size distribution
Grinding speed: Although the increase of speed can accelerate the reduction of particle size, the impact on the final material size is not decisive.
There is a delicate balance between the rotational speed and the grinding time, indicating that the optimization of the grinding time is more critical within a certain range.
The picture shows the working principle diagram of wet nano lapping of Boyi experimental machine
Grinding time: With the extension of grinding time, the drug particles are gradually refined, but excessive grinding may lead to particle agglomeration or crystal transformation, so precise control is required.
Picture: Boyi reactor
The use of dispersant: as a key factor to control the particle size of nanoparticles, the addition of dispersant can effectively reduce the interaction force between particles, prevent agglomeration, and ensure the stable dispersion of nanoparticles.
In the field of drug development and production, the dissolution rate and solubility of drugs are the key indicators to measure the quality of drugs.
Picture: Boyi ingredient tank
Wet nano grinding technology provides a new solution to solve the difficult problem of insoluble drugs.
